MicroRNA regulation of HS biosynthesis
نویسندگان
چکیده
Background: Heparan sulfate proteoglycan (HSPG) coreceptors modulate VEGFA signaling. Results: MicroRNA-24 targets NDST1 to reduce HS sulfation and HS affinity for VEGFA, suppressing VEGFA signaling and endothelial cell migration. Conclusion: MicroRNAs targeting HS biosynthesis can regulate VEGFA-induced chemotaxis, essential during angiogenesis. Significance: HSPG-dependent signaling of pathophysiological importance can be targeted via microRNA interference with HS biosynthesis.
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